BACKGROUND The arms race between prokaryotes and their perpetually evolving predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas) systems store the memory of past encounters with foreign DNA in unique …
Many prokaryotes encode CRISPR-Cas systems as immune protection against mobile genetic elements (MGEs), yet a number of MGEs also harbor CRISPR-Cas components …
Highlights•Precision antimicrobials represent a novel approach for treating infectious diseases.•The role of the microbiota in health and disease is indisputable and so is the need …
CRISPR-Cas adaptive immune systems capture DNA fragments from invading bacteriophages and plasmids and integrate them as spacers into bacterial CRISPR arrays …
Prokaryotes use CRISPR–Cas systems for adaptive immunity, but the reasons for the frequent existence of multiple CRISPRs and cas clusters remain poorly understood. Here …
S Shehreen, T Chyou, PC Fineran… - … Transactions of the …, 2019 - royalsocietypublishing.org
CRISPR-Cas systems are widespread in bacterial and archaeal genomes, and in their canonical role in phage defence they confer a fitness advantage. However, CRISPR-Cas …
Highlights•The reported diversity of HGT strategies in prokaryotes has recently increased.•HGT could require MGE or be MGE-independent.•Some MGE only mobilize their …
ABSTRACT CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against invading genetic elements, such as plasmids, bacteriophages and archaeal viruses …