Proenkephalin: a new biomarker for glomerular filtration rate and acute kidney injury
M Khorashadi, R Beunders, P Pickkers, M Legrand - Nephron, 2020 - karger.com
Assessment of kidney function is primarily based on urine output and Creatinine (Cr)-based
methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not …
methods to estimate glomerular filtration rate (GFR). The latter is confounded as Cr is not …
Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis
Abstract Background Proenkephalin A 119-159 (PENK) is freely filtered in the glomerulus
with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been …
with plasma levels correlating with glomerular filtration rate. Therefore, PENK has been …
Incidence and outcome of subclinical acute kidney injury using penKid in critically ill patients
Rationale: Subclinical acute kidney injury (sub-AKI) refers to patients with low serum
creatinine but elevated alternative biomarkers of AKI. Its incidence and outcome in critically …
creatinine but elevated alternative biomarkers of AKI. Its incidence and outcome in critically …
Proenkephalin compared to conventional methods to assess kidney function in critically ill sepsis patients
R Beunders, R van Groenendael, GP Leijte, M Kox… - Shock, 2020 - journals.lww.com
Background: The assessment of renal function in clinical practice remains challenging.
Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, and …
Using creatinine to assess the glomerular filtration rate (GFR) is notoriously inaccurate, and …
[HTML][HTML] Advances in laboratory detection of acute kidney injury
Recent advances have improved our understanding of the epidemiology and
pathophysiology of acute kidney injury (AKI). So far, the Kidney Disease: Improving Global …
pathophysiology of acute kidney injury (AKI). So far, the Kidney Disease: Improving Global …
Biomarkers improve diagnostics of sepsis in adult patients with suspected organ dysfunction based on the quick sepsis-related organ failure assessment (qSOFA) …
M Bolanaki, J Winning, A Slagman… - Critical Care …, 2024 - journals.lww.com
OBJECTIVES: Consensus regarding biomarkers for detection of infection-related organ
dysfunction in the emergency department is lacking. We aimed to identify and validate …
dysfunction in the emergency department is lacking. We aimed to identify and validate …
Proenkephalin, an opioid system surrogate, as a novel comprehensive renal marker in heart failure
JE Emmens, JM Ter Maaten, K Damman… - Circulation: Heart …, 2019 - Am Heart Assoc
Background: PENK (proenkephalin) is a stable surrogate for enkephalins, endogenous
opioid peptides, which exert cardiodepressive effects and improve renal function. PENK has …
opioid peptides, which exert cardiodepressive effects and improve renal function. PENK has …
[HTML][HTML] Role of proenkephalin in the diagnosis of severe and subclinical acute kidney injury during the perioperative period of liver transplantation
In recent decades, clinical research on early biomarkers of renal injury has been frequent
and intensive, with proenkephalin (PENK) being indicated as a promising filtration …
and intensive, with proenkephalin (PENK) being indicated as a promising filtration …
Proenkephalin A 119–159 predicts early and successful liberation from renal replacement therapy in critically ill patients with acute kidney injury: a post hoc analysis …
T von Groote, F Albert, M Meersch, R Koch, C Porschen… - Critical Care, 2022 - Springer
Background Renal replacement therapy (RRT) remains the key rescue therapy for critically
ill patients with severe acute kidney injury (AKI). However, there are currently no tools …
ill patients with severe acute kidney injury (AKI). However, there are currently no tools …
Proenkephalin A as a marker for glomerular filtration rate in critically ill children: validation against gold standard iohexol GFR measurements
NJL Smeets, O Hartmann, J Schulte… - Clinical Chemistry and …, 2023 - degruyter.com
Objectives Accurate determination of glomerular filtration rate (GFR) is important. Several
endogenous biomarkers exist for estimating GFR, yet, they have limited accuracy, especially …
endogenous biomarkers exist for estimating GFR, yet, they have limited accuracy, especially …