Mitochondrial metabolism in astrocytes regulates brain bioenergetics, neurotransmission and redox balance

J Rose, C Brian, A Pappa, MI Panayiotidis… - Frontiers in …, 2020 - frontiersin.org
In the brain, mitochondrial metabolism has been largely associated with energy production,
and its dysfunction is linked to neuronal cell loss. However, the functional role of …

Astrocytes in Alzheimer's disease: pathological significance and molecular pathways

P Preman, M Alfonso-Triguero, E Alberdi… - Cells, 2021 - mdpi.com
Astrocytes perform a wide variety of essential functions defining normal operation of the
nervous system and are active contributors to the pathogenesis of neurodegenerative …

The tripartite glutamatergic synapse

U Lalo, W Koh, CJ Lee, Y Pankratov - Neuropharmacology, 2021 - Elsevier
Astroglial cells were long considered as structural and metabolic supporting cells are which
do not directly participate in information processing in the brain. Discoveries of …

Why are astrocytes important?

A Verkhratsky, M Nedergaard, L Hertz - Neurochemical research, 2015 - Springer
Astrocytes, which populate the grey and white mater of the brain and the spinal cord are
highly heterogeneous in their morphology and function. These cells are primarily …

Glucose, lactate, and shuttling of metabolites in vertebrate retinas

JB Hurley, KJ Lindsay, J Du - Journal of neuroscience research, 2015 - Wiley Online Library
The vertebrate retina has specific functions and structures that give it a unique set of
constraints on the way in which it can produce and use metabolic energy. The retina's …

Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission

C Murphy‐Royal, J Dupuis, L Groc… - Journal of …, 2017 - Wiley Online Library
Astrocytes, the major glial cell type in the central nervous system (CNS), are critical for brain
function and have been implicated in various disorders of the central nervous system. These …

The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders

SM O'Donovan, CR Sullivan, RE McCullumsmith - npj Schizophrenia, 2017 - nature.com
Altered glutamate transporter expression is a common feature of many neuropsychiatric
conditions, including schizophrenia. Excitatory amino acid transporters (EAATs) are …

Neuroglial transmission

V Gundersen, J Storm-Mathisen… - Physiological …, 2015 - journals.physiology.org
Neuroglia, the “glue” that fills the space between neurons in the central nervous system,
takes active part in nerve cell signaling. Neuroglial cells, astroglia, oligodendroglia, and …

Brain energy metabolism: A roadmap for future research

CD Rae, JA Baur, K Borges, G Dienel… - Journal of …, 2024 - Wiley Online Library
Although we have learned much about how the brain fuels its functions over the last
decades, there remains much still to discover in an organ that is so complex. This article lays …

Progressive decrease of mitochondrial motility during maturation of cortical axons in vitro and in vivo

TL Lewis, GF Turi, SK Kwon, A Losonczy, F Polleux - Current Biology, 2016 - cell.com
The importance of mitochondria for neuronal function is evident by the large number of
neurodegenerative diseases that have been associated with a disruption of mitochondrial …