Population pharmacokinetics of amodiaquine and piperaquine in African pregnant women with uncomplicated Plasmodium falciparum infections
J Ding, RM Hoglund, H Tagbor, H Tinto… - CPT …, 2024 - Wiley Online Library
Artemisinin‐based combination therapy (ACT) is the first‐line recommended treatment for
uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often …
uncomplicated malaria. Pharmacokinetic (PK) properties in pregnant women are often …
Impact of Pregnancy on the Pharmacokinetics and Metabolism of Nicotinamide in Humans
MM Fashe, TV Le, MN Gower… - Clinical …, 2024 - Wiley Online Library
In pre‐eclampsia models, nicotinamide (NAM) has protective effects in pre‐eclampsia and is
being evaluated as a therapeutic nutraceutical in clinical studies. NAM undergoes extensive …
being evaluated as a therapeutic nutraceutical in clinical studies. NAM undergoes extensive …
Impact of Sex and Pregnancy on Hepatic CYP3A4 Expression and Activity in a Humanized Mouse Model
MM Fashe, TA Miner, VL Collazo, JT Grieco… - Drug Metabolism and …, 2024 - Elsevier
Abstract Cytochrome P450 3A4 (CYP3A4) is an essential drug-metabolizing enzyme in
humans, which shows substantial interindividual variation in response to various intrinsic …
humans, which shows substantial interindividual variation in response to various intrinsic …
Physiologically Based Pharmacokinetic Modeling in Pregnancy, during Lactation and in Neonates: Achievements, Challenges and Future Directions
Obstetric subjects represent a special population in pharmacology. During pregnancy and in
the postpartum period, various anatomical and physiological changes give rise to altered …
the postpartum period, various anatomical and physiological changes give rise to altered …