Abstract Development of the forebrain critically depends on the Sonic Hedgehog (Shh)
signaling pathway, as illustrated in humans by the frequent perturbation of this pathway in …

Abstract The Bardet Biedl syndrome (BBS) is a rare inherited disorder considered a model of
non-motile ciliopathy. It is in fact caused by mutations of genes encoding for proteins mainly …

Bardet–Biedl syndrome (BBS) is an autosomal recessive multisystemic human genetic
disorder characterized by six major defects including obesity, mental retardation, renal …

Bardet‐Biedl syndrome (BBS) is a recessive genetic disease causing multiple organ
anomalies. Most patients carry mutations in genes encoding for the subunits of the BBSome …

The primary cilium is a highly specialized and evolutionary conserved organelle in
eukaryotes that plays a significant role in cell signaling and trafficking. Over the past few …

Olfactory dysfunctions affect a larger portion of population (up to 15% with partial olfactory
loss, and 5% with complete olfactory loss) as compared to other sensory dysfunctions (eg …

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The development of therapies for retinal disorders is hampered by a lack of appropriate
animal models. Higher nonhuman primates are the only animals with retinal structure similar …

Olfactory dysfunction is a pervasive but underappreciated health concern that affects
personal safety and quality of life. Patients with olfactory dysfunctions have limited …

Primary cilia are organelles that are present on many different cell types, either transiently or
permanently. They play a crucial role in receiving signals from the environment and passing …