NF-kB and inflammatory cytokine signalling: role in skeletal muscle atrophy

A Thoma, AP Lightfoot - Muscle Atrophy, 2018 - Springer
Atrophy is a classical hallmark of an array of disorders that affect skeletal muscle, ranging
from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and …

Age-related changes in skeletal muscle: changes to life-style as a therapy

R McCormick, A Vasilaki - Biogerontology, 2018 - Springer
As we age, there is an age-related loss in skeletal muscle mass and strength, known as
sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an …

Mitochondrial ROS regulate oxidative damage and mitophagy but not age-related muscle fiber atrophy

GK Sakellariou, T Pearson, AP Lightfoot, GA Nye… - Scientific reports, 2016 - nature.com
Age-related loss of skeletal muscle mass and function is a major contributor to morbidity and
has a profound effect on the quality of life of older people. The potential role of age …

Lactobacillus plantarum HY7715 Ameliorates Sarcopenia by Improving Skeletal Muscle Mass and Function in Aged Balb/c Mice

K Lee, J Kim, SD Park, JJ Shim, JL Lee - International Journal of …, 2021 - mdpi.com
Sarcopenia is a loss of muscle mass and function in elderly people and can lead to physical
frailty and fall-related injuries. Sarcopenia is an inevitable event of the aging process that …

[HTML][HTML] SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets

L Yang, D Liu, S Jiang, H Li, L Chen, Y Wu… - Biomedicine & …, 2024 - Elsevier
Sarcopenia is an aging-related skeletal disease characterized by decreased muscle mass,
strength, and physical function, severely affecting the quality of life (QoL) of the elderly …

[HTML][HTML] The mitochondrial antioxidant SS-31 increases SIRT1 levels and ameliorates inflammation, oxidative stress and leukocyte-endothelium interactions in type 2 …

I Escribano-Lopez, N Diaz-Morales, F Iannantuoni… - Scientific Reports, 2018 - nature.com
There is growing focus on mitochondrial impairment and cardiovascular diseases (CVD) in
type 2 diabetes (T2D), and the development of novel therapeutic strategies in this context. It …

Transcriptome analysis of immune receptor activation and energy metabolism reduction as the underlying mechanisms in interleukin-6-induced skeletal muscle …

H Sun, J Sun, M Li, L Qian, L Zhang, Z Huang… - Frontiers in …, 2021 - frontiersin.org
Background Inflammation may trigger skeletal muscle atrophy induced by cancer cachexia.
As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the …

The role of myokines in muscle health and disease

AP Lightfoot, RG Cooper - Current opinion in rheumatology, 2016 - journals.lww.com
The role of myokines in muscle health and disease : Current Opinion in Rheumatology The role
of myokines in muscle health and disease : Current Opinion in Rheumatology Log in or …

Cellular mechanisms underlying oxidative stress in human exercise

MJ Jackson, A Vasilaki, A McArdle - Free radical biology and medicine, 2016 - Elsevier
A relative increase in oxidation of lipids, proteins and DNA has been recognised to occur in
the circulation and tissues of exercising humans and animals since the late 1970s and …

The effect of disease-modifying anti-rheumatic drugs on skeletal muscle mass in rheumatoid arthritis patients: a systematic review with meta-analysis

TR Hein, L Peterson, BJ Bartikoski, J Portes… - Arthritis research & …, 2022 - Springer
Introduction Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic
and systemic inflammation. Besides, it is known that RA patients may present several …