BACKGROUND: The tripeptide γ-glutamylcysteinylglycine or glutathione (GSH) has
demonstrated protective abilities against the detrimental effects of oxidative stress within the …

Over the past seven decades, research on autotrophic and heterotrophic model organisms
has defined how the flow of electrons (“reducing power”) from high-energy inorganic …

Significance: Parasitic infections continue to be a major problem for global human health.
Vaccines are practically not available and chemotherapy is highly unsatisfactory. One …

BACKGROUND: There are two, largely autonomous antioxidant pathways in many
organisms, one based on thioredoxin and one based on glutathione, with each pathway …

Significance: Platyhelminth parasites cause chronic infections that are a major cause of
disability, mortality, and economic losses in developing countries. Maintaining redox …

Background Schistosomiasis remains a major public health concern affecting billions of
people around the world. Currently, praziquantel is the only drug of choice for treatment of …

Schistosomiasis is the second most widespread human parasitic disease. It is principally
treated with one drug, praziquantel, that is administered to 100 million people each year; …

More than 2 billion people are infected with helminth parasites across the globe. The
burgeoning drug resistance against current anthelmintics in parasitic worms of humans and …

The mammalian thioredoxin system is driven by NADPH through the activities of isoforms of
the selenoprotein thioredoxin reductase (TXNRD, TrxR), which in turn help to keep …

The enzyme glucose-6-phosphate dehydrogenase (G6PDH) plays crucial roles in glucose
homeostasis and the pentose phosphate pathway (PPP), being also involved in redox …