CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

Activation of oncogenes or the deactivation of tumor suppressor genes has long been
established as the fundamental mechanism leading towards carcinogenesis. Although this …

Abstract The Eyes Absent (EYA) family of proteins is an atypical group of four dual-
functioning protein phosphatases (PP), which have been linked to many vital cellular …

Whole genome bisulfite sequencing (WGBS), with its ability to interrogate methylation status
at single CpG site resolution epigenome-wide, is a powerful technique for use in molecular …

5-methyl cytosine (5mC) is a key epigenetic mark entwined with gene expression and the
specification of cellular phenotypes. Its distribution around gene promoters sets a barrier for …

Abstract Background The current Union International Committee on Cancer or the American
Joint Committee on Cancer TNM stage system has shown valuable but insufficient …

SRY-related high-mobility group box 9 (SOX9) is an indispensable transcription factor that
regulates multiple developmental pathways related to stemness, differentiation, and …

Epigenetics refers to alterations in gene expression due to differential histone modifications
and DNA methylation at promoter sites of genes. Epigenetic alterations are reversible and …

Renal fibrosis is the common histopathological feature of chronic kidney diseases (CKD),
and there is increasing evidence that epigenetic regulation is involved in the occurrence and …