Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke

X Nie, X Leng, Z Miao, M Fisher, L Liu - Stroke, 2023 - Am Heart Assoc
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

Review of current large core volume stroke thrombectomy clinical trials: controversies and progress

Z Ren, X Huo, J Kumar, AP Jadhav… - Stroke: vascular and …, 2022 - Am Heart Assoc
Large clinical trials have helped establish the benefit of endovascular treatment (EVT) in
patients with acute ischemic stroke with large vessel occlusion and small infarct core volume …

Association between recanalization attempts and functional outcome after thrombectomy for large ischemic stroke

L Winkelmeier, TD Faizy, G Broocks, L Meyer… - Stroke, 2023 - Am Heart Assoc
BACKGROUND: Recently, 3 randomized controlled trials provided high-level evidence that
patients with large ischemic stroke achieved better functional outcomes after endovascular …

Edema reduction versus penumbra salvage: investigating treatment effects of mechanical thrombectomy in ischemic stroke

G Broocks, A Kemmling, H Kniep, L Meyer… - Annals of …, 2024 - Wiley Online Library
Objective Mechanical thrombectomy (MT) is of benefit to patients with ischemic stroke;
however, the effect of recanalization on lesion pathophysiology is not yet well understood …

Patients with low Alberta Stroke Program Early CT Score (ASPECTS) but good collaterals benefit from endovascular recanalization

G Broocks, H Kniep, P Schramm, U Hanning… - Journal of …, 2020 - jnis.bmj.com
Background Benefit of thrombectomy in patients with a low initial Alberta Stroke Program
Early CT Score (ASPECTS) is still uncertain. We hypothesized that, despite low ASPECTS …

Lesion age imaging in acute stroke: water uptake in CT versus DWI‐FLAIR mismatch

G Broocks, H Leischner, U Hanning… - Annals of …, 2020 - Wiley Online Library
Purpose In acute ischemic stroke with unknown time of onset, magnetic resonance (MR)‐
based diffusion‐weighted imaging (DWI) and fluid‐attenuated inversion recovery (FLAIR) …

Brain edema growth after thrombectomy is associated with comprehensive collateral blood flow

TD Faizy, L Winkelmeier, M Mlynash… - Journal of …, 2024 - jnis.bmj.com
Background We determined whether a comprehensive assessment of cerebral collateral
blood flow is associated with ischemic lesion edema growth in patients successfully treated …

Mediation of successful reperfusion effect through infarct growth and cerebral edema: a pooled, patient‐level analysis of EXTEND‐IA trials and SELECT prospective …

A Sarraj, DK Pujara, L Churilov, CW Sitton… - Annals of …, 2023 - Wiley Online Library
Objective Reperfusion therapy is highly beneficial for ischemic stroke. Reduction in both
infarct growth and edema are plausible mediators of clinical benefit with reperfusion. We …

Reversible ischemic lesion hypodensity in acute stroke CT following endovascular reperfusion

G Broocks, R McDonough, L Meyer, M Bechstein… - Neurology, 2021 - AAN Enterprises
Background and Objectives In acute stroke, early ischemic lesion hypodensity on CT is
considered the imaging hallmark of brain infarction, representing a state of irreversible …

Review of net water uptake in the management of acute ischemic stroke

XQ Cheng, JQ Shi, H Wu, WS Zhu, GM Lu - European Radiology, 2022 - Springer
CT densitometry-based methods to directly quantify net water uptake in ischemic brain
tissue have been increasingly applied recently. There is potential for net water uptake to be …