Organs-on-chips have emerged as viable platforms for drug screening and personalized
medicine. While a wide variety of human organ-on-a-chip models have been developed …

Microfluidics opened the possibility to model the physiological environment by controlling
fluids flows, and therefore nutrients supply. It allows to integrate external stimuli such as …

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Introduction We hypothesized that engineering a combined lymph node/melanoma organoid
from the same patient would allow tumor, stroma, and immune system to remain viable for …

Current drug development techniques are expensive and inefficient, partially due to the use
of preclinical models that do not accurately recapitulate in vivo drug efficacy and cytotoxicity …

Bone is an active organ that continuously undergoes an orchestrated process of remodeling
throughout life. Bone tissue is uniquely capable of adapting to loading, hormonal, and other …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …

Cell‐based living materials, including single cells, cell‐laden fibers, cell sheets, organoids,
and organs, have attracted intensive interests owing to their widespread applications in …

Primary cancer modulates the bone microenvironment to sow the seeds of dormancy and
metastasis in tumor cells, leading to multiple organ metastasis and death. In this study, 3D …

We explore the utility of bioengineered human tissues—individually or connected into
physiological units—for biological research. While much smaller and simpler than their …