Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Human pancreatic plasticity is implied from multiple single-cell RNA sequencing (scRNA-
seq) studies. However, these have been invariably based on static datasets from which fate …

Background. Mankind continues to suffer from the ever‐growing diabetes epidemic and the
rapid rise of type 2 diabetes mellitus (T2DM). This metabolic disease has been studied since …

Abstract β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store
and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively …

The unexpected rise in cancer and diabetes statistics has been a significant global threat,
inciting ongoing research into various biomarkers that can act as innovative therapeutic …

Background Therapeutic replacement of pancreatic endocrine β-cells is key to improving
hyperglycaemia caused by insulin-dependent diabetes. Whilst the pool of ductal …

Stem cell‐related therapeutic technologies have garnered significant attention of the
research community for their multi‐faceted applications. To promote the therapeutic effects …

Objectives Cancer and diabetes are two diseases known to bypass socio-demographic
segregation, hence the increased focus on their molecular mechanism for therapeutic …

Abstract Prostaglandin E2 (PGE2) is a key mediator of inflammation and is derived from the
omega-6 polyunsaturated fatty acid, arachidonic acid (AA). In the β-cell, the PGE2 receptor …

Objectives: Cancer and diabetes are two diseases known to bypass socio-demographic
segregation, hence the increased focus on their molecular mechanism for therapeutic …