The Hedgehog-GLI (HH-GLI) pathway is a highly conserved signaling that plays a critical
role in controlling cell specification, cell–cell interaction and tissue patterning during …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

Hedgehog signalling is crucial for development and is deregulated in several tumours,
including medulloblastoma. Regulation of the transcriptional activity of Gli (glioma …

Although the framework of the Hedgehog (Hh) signaling pathway is evolutionarily
conserved, recent studies indicate that fundamental differences exist between Drosophila …

Ski and the closely related SnoN were discovered as oncogenes by their ability to transform
chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and …

Sonic hedgehog (Shh) acts as a morphogen to mediate the specification of distinct cell
identities in the ventral neural tube through a Gli-mediated (Gli1-3) transcriptional network …

The Hedgehog signaling pathway is essential for many aspects of normal embryonic
development, including formation and patterning of the neural tube. Absence of the sonic …

The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating
many physiological processes in development and tissue homeostasis. The TGF-β signaling …