Helicases are ubiquitous enzymes found in all organisms that are necessary for all (or
virtually all) aspects of nucleic acid metabolism. The Pif1 helicase family is a group of 5′→ …

Pif1 family helicases have multiple roles in the maintenance of nuclear and mitochondrial
DNA in eukaryotes. Saccharomyces cerevisiae Pif1 is involved in replication through …

Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3
promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify …

The two PIF1 family helicases in Saccharomyces cerevisiae, Rrm3, and ScPif1, associate
with thousands of sites throughout the genome where they perform overlapping and distinct …

Replication forks encounter impediments as they move through the genome, including
natural barriers due to stable protein complexes and highly transcribed genes. Unlike …

An R-loop is a structure that forms when an RNA transcript stays bound to the DNA strand
that encodes it and leaves the complementary strand exposed as a loop of single stranded …

Trichothecene mycotoxins synthesized by Fusarium species are potent inhibitors of
eukaryotic translation. They are encountered in both the environment and in food, posing a …

Pif1 helicase plays various roles in the maintenance of nuclear and mitochondrial genome
integrity in most eukaryotes. Here, we used a proteomics approach called isotopic …

Targeted protein degradation systems developed for eukaryotes employ cytoplasmic
machineries to perform proteolysis. This has prevented mitochondria-specific analysis of …

All cells have the ability to adjust their metabolism to their changing environment to be able
to survive. This adaptation is coordinated by various systems in the cell and mitochondria …