ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes
AYH Woo, L Jia - … Research-Fundamental and Molecular Mechanisms of …, 2024 - Elsevier
Reactive aldehydes, for instance, formaldehyde and acetaldehyde, are important
endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion …
endogenous or environmental mutagens by virtue of their abilities to produce a DNA lesion …
A glycolytic metabolite bypasses “two-hit” tumor suppression by BRCA2
Summary Knudson's" two-hit" paradigm posits that carcinogenesis requires inactivation of
both copies of an autosomal tumor suppressor gene. Here, we report that the glycolytic …
both copies of an autosomal tumor suppressor gene. Here, we report that the glycolytic …
Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA …
We have identified a set of Japanese children with hypoplastic anemia caused by combined
defects in aldehyde degrading enzymes ADH5 and ALDH2. Their clinical characteristics …
defects in aldehyde degrading enzymes ADH5 and ALDH2. Their clinical characteristics …
The mutagenic properties of formaldehyde and acetaldehyde: reflections on half a century of progress
MJ Thapa, K Chan - … Research-Fundamental and Molecular Mechanisms of …, 2024 - Elsevier
Formaldehyde and acetaldehyde are reactive, small compounds that humans are exposed
to routinely, variously from endogenous and exogenous sources. Both small aldehydes are …
to routinely, variously from endogenous and exogenous sources. Both small aldehydes are …