Natural antibodies (NAb) are defined as germline encoded immunoglobulins found in
individuals without (known) prior antigenic experience. NAb bind exogenous (eg, bacterial) …

Antibodies that are specific to organ donor HLA have been involved in the majority of cases
of antibody-mediated rejection in solid organ transplant recipients. However, recent data …

Autoantibodies to components of apoptotic cells, such as anti-perlecan antibodies,
contribute to rejection in organ transplant recipients. However, mechanisms of immunization …

Intrarenal B cells in human renal allografts indicate transplant recipients with a poor
prognosis, but how these cells contribute to rejection is unclear. Here we show using single …

Allograft rejection remains the major hurdle in lung transplantation despite modern
immunosuppressive treatment. As part of the alloreactive process, B cells are increasingly …

Background Cardiac allograft vasculopathy (CAV) has been associated with graft-infiltrating
B cells, although their characteristics are still unclear. In this study we examined the …

Background The development of antibodies specific to HLA expressed on donor tissue
(donor-specific antibodies [DSAs]) is a prominent risk factor for kidney graft loss. Non-HLA …

Pretransplant autoantibodies to LG3 and angiotensin II type 1 receptors (AT1R) are
associated with acute rejection in kidney transplant recipients, whereas antivimentin …

Background Pre-transplant sensitization is a limiting factor in solid-organ transplantation. In
heart transplants, ventricular assist device (VAD) implantation has been associated with …

HLA antibodies play a major role in the recipient's immune response against the renal
allograft and are an established risk factor for antibody-mediated rejection and subsequent …