Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …

Voltage-gated calcium channels couple depolarization of the cell-surface membrane to entry
of calcium, which triggers secretion, contraction, neurotransmission, gene expression, and …

Learning is primarily mediated by activity-dependent modifications of synaptic strength
within neuronal circuits. We discovered that place fields in hippocampal area CA1 are …

The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene
transcription. It is generally accepted that E–TC makes a crucial contribution to learning and …

Understanding the mechanisms underlying autism spectrum disorders (ASDs) is a
challenging goal. Here we review recent progress on several fronts, including genetics …

Astrocytes control excitatory synaptogenesis by secreting thrombospondins (TSPs), which
function via their neuronal receptor, the calcium channel subunit α2δ-1. α2δ-1 is a drug …

The Cav3. 2 subtype of T-type calcium channels has been targeted for developing
analgesics and anti-epileptics for its role in pain and epilepsy. Here we present the cryo-EM …

Psychiatric disorders are mental, behavioral or emotional disorders. These conditions are
prevalent, one in four adults suffer from any type of psychiatric disorders world-wide. It has …