Multifaceted roles of APOE in Alzheimer disease

RJ Jackson, BT Hyman, A Serrano-Pozo - Nature Reviews Neurology, 2024 - nature.com
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium

YT Quiroz, M Solis, MP Aranda, AI Arbaje… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract The Alzheimer's Association hosted the second Latinos & Alzheimer's Symposium
in May 2021. Due to the COVID‐19 pandemic, the meeting was held online over 2 days, with …

Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample

MS Naslavsky, CK Suemoto, LA Brito, MO Scliar… - Molecular …, 2022 - nature.com
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

Blood biomarkers from research use to clinical practice: What must be done? A report from the EU/US CTAD Task Force

D Angioni, J Delrieu, O Hansson, H Fillit… - The journal of …, 2022 - Springer
Timely and accurate diagnosis of Alzheimer's disease (AD) in clinical practice remains
challenging. PET and CSF biomarkers are the most widely used biomarkers to aid diagnosis …

Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos

Y Zhang, M Elgart, E Granot-Hershkovitz, H Wang… - …, 2023 - thelancet.com
Background Sleep phenotypes have been reported to be associated with cognitive ageing
outcomes. However, there is limited research using genetic variants as proxies for sleep …

[Retracted] Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer's Disease: A …

C Liu, X Guo, X Chang - BioMed Research International, 2022 - Wiley Online Library
Objective. The clinical value of intestinal flora balance therapy based on probiotic support in
improving cognitive function and symptoms of patients with Alzheimer's disease was to …

APOE and immunity: Research highlights

CM Kloske, CJ Barnum, AF Batista… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION At the Alzheimer's Association's APOE and Immunity virtual conference,
held in October 2021, leading neuroscience experts shared recent research advances on …

NeuroEPO plus (NeuralCIM®) in mild-to-moderate Alzheimer's clinical syndrome: the ATHENEA randomized clinical trial

S Sosa, G Bringas, N Urrutia, AI Peñalver… - Alzheimer's Research & …, 2023 - Springer
Background NeuroEPO plus is a recombinant human erythropoietin without erythropoietic
activity and shorter plasma half-life due to its low sialic acid content. NeuroEPO plus …

Sex and APOE genotype alter the basal and induced inflammatory states of primary microglia from APOE targeted replacement mice

I Mhatre-Winters, A Eid, Y Han, K Tieu… - International Journal of …, 2022 - mdpi.com
The sex and APOE4 genotype are significant risk factors for Alzheimer's disease (AD);
however, the mechanism (s) responsible for this interaction are still a matter of debate. Here …

Apolipoprotein E (APOE) genotype, dementia, and memory performance among Caribbean Hispanic versus US populations

JJ Llibre‐Guerra, J Li, Y Qian… - Alzheimer's & …, 2023 - Wiley Online Library
Abstract Introduction Apolipoprotein E (APOE) is considered the major susceptibility gene for
developing Alzheimer's disease. However, the strength of this risk factor is not well …