Molecular mechanisms of morphine tolerance and dependence; novel insights and future perspectives
Drug addiction is a devastating condition that poses a serious burden on the society. The
use of some drugs like morphine for their tremendous analgesic properties is also …
use of some drugs like morphine for their tremendous analgesic properties is also …
Endogenous opiates and behavior: 2014
RJ Bodnar - Peptides, 2016 - Elsevier
This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …
concerning the endogenous opioid system. It summarizes papers published during 2014 …
PPARs and pain
Chronic pain is a common cause of disability worldwide and remains a global health and
socio‐economic challenge. Current analgesics are either ineffective in a significant …
socio‐economic challenge. Current analgesics are either ineffective in a significant …
The PPARγ agonist pioglitazone produces a female-predominant inhibition of hyperalgesia associated with surgical incision, peripheral nerve injury, and painful …
Pioglitazone, an agonist at peroxisome proliferator-activated receptor gamma, is FDA-
approved for the treatment of insulin resistance in type 2 diabetes. Numerous studies in …
approved for the treatment of insulin resistance in type 2 diabetes. Numerous studies in …
Peroxisome proliferator activated receptor-gamma (PPAR-γ) ligand, pioglitazone, increases analgesic and anti-inflammatory effects of naproxen
R Haddadi, M Cheraghi-Poor - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
The aim of this study was the investigation of analgesic and anti-inflammatory activity of
naproxen and pioglitazone following intra-plantar injection of carrageenan and assessment …
naproxen and pioglitazone following intra-plantar injection of carrageenan and assessment …
Morphine-mediated brain region-specific astrocytosis involves the ER stress-autophagy axis
A recent study from our lab has revealed a link between morphine-mediated autophagy and
synaptic impairment. The current study was aimed at investigating whether morphine …
synaptic impairment. The current study was aimed at investigating whether morphine …
Venlafaxine prevents morphine antinociceptive tolerance: the role of neuroinflammation and the l-arginine-nitric oxide pathway
MT Mansouri, B Naghizadeh, B Ghorbanzadeh… - Experimental …, 2018 - Elsevier
Opioid-induced neuroinflammation and the nitric oxide (NO) signal-transduction pathway
are involved in the development of opioid analgesic tolerance. The antidepressant …
are involved in the development of opioid analgesic tolerance. The antidepressant …
Angiotensin II receptor type 1 blocker candesartan improves morphine tolerance by reducing morphine‑induced inflammatory response and cellular activation of BV2 …
W Zhao, F Shen, J Yao, S Su… - Molecular Medicine …, 2022 - spandidos-publications.com
Morphine is the most common drug of choice in clinical pain management; however,
morphine tolerance presents a significant clinical challenge. The pathogenesis of morphine …
morphine tolerance presents a significant clinical challenge. The pathogenesis of morphine …
Potential of glial cell modulators in the management of substance use disorders
JD Jones - CNS drugs, 2020 - Springer
The pervasive and devastating nature of substance use disorders underlies the need for the
continued development of novel pharmacotherapies. We now know that glia play a much …
continued development of novel pharmacotherapies. We now know that glia play a much …
Neuroprotection of donepezil against morphine-induced apoptosis is mediated through Toll-like receptors
A Shafie, F Moradi, E Izadpanah, A Mokarizadeh… - European Journal of …, 2015 - Elsevier
Previously, we had shown that donepezil provides anti-apoptotic effects associated with the
prevention of morphine tolerance to the analgesic effect. In this regard, the present study …
prevention of morphine tolerance to the analgesic effect. In this regard, the present study …