Juvenile idiopathic arthritis (JIA) is an umbrella term for arthritis of unknown origin, lasting
for> 6 weeks with onset before 16 years of age. JIA is the most common chronic …

Purpose—Much has transpired since the last scientific statement on pediatric stroke was
published 10 years ago. Although stroke has long been recognized as an adult health …

Abstract Deficiency of ADA2 (DADA2) is the first molecularly described monogenic vasculitis
syndrome. DADA2 is caused by biallelic hypomorphic mutations in the ADA2 gene that …

Systemic vasculitides are multisystem blood vessel disorders, which are defined by the size
of the vessel predominantly affected, namely small, medium, or large vessels. The term …

Adenosine Deaminase 2 Deficiency and TNF Inhibition The manifestations of a deficiency of
adenosine deaminase 2, a genetic disease, include early-onset lacunar stroke. In a series of …

Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Background Deficiency of adenosine deaminase 2 (DADA2) is a syndrome with pleiotropic
manifestations including vasculitis and hematologic compromise. A systematic definition of …

The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessively inherited
disease that has undergone extensive phenotypic expansion since being first described in …

Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal-recessive loss-of-
function mutations in the ADA2 gene (previously known as CECR1) results in a systemic …

Deficiency of adenosine deaminase 2 (DADA2) is caused by biallelic deleterious mutations
in CECR1. DADA2 results in variable autoinflammation and vasculopathy (recurrent fevers …