Histones are integral components of eukaryotic chromatin that have a pivotal role in the
organization and function of the genome. The dynamic regulation of chromatin involves the …

Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the
nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and …

The histone variant CENP-A is the epigenetic determinant for the centromere, where it is
interspersed with canonical H3 to form a specialized chromatin structure that nucleates the …

Eukaryotes have a multitude of diverse mechanisms for organising and using their
genomes, but the histones that make up chromatin are highly conserved. Unusually …

Chromatin is a dynamic molecular complex composed of DNA and proteins that package the
DNA in the nucleus of eukaryotic cells. The basic structural unit of chromatin is the …

Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

The intricacies of the 3D hierarchical organization of the genome have been approached by
many creative modeling studies. The specific model/simulation technique combination …

Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …

Throughout the genome, nucleosomes often form regular arrays that differ in nucleosome
repeat length (NRL), occupancy of linker histone H1 and transcriptional activity. Here, we …

Understanding the function of eukaryotic genomes, including the human genome, is
undoubtedly one of the major scientific challenges of the 21st century. The cornerstone of …