With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

MP adds a further element of complexity in the process of assessing the quality of a liver
graft. Understanding the physiology of the parameters included in the different assessment …

Hypothermic Oxygenated Perfusion (HOPE) of the liver can reduce the incidence of early
allograft dysfunction (EAD) and failure in extended criteria donors (ECD) grafts, although …

Background & Aims Machine perfusion is increasingly being tested in clinical
transplantation. Despite this, the number of large prospective clinical trials remains limited …

Conclusions: HMP-O 2 demonstrates safety and noninferior efficacy for liver graft
preservation in comparison to SCS. Early allograft failure by L-GrAFT 7 was lower in HMP-O …

End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an
effective strategy to recover liver grafts having initially been discarded for liver …

Background: The increasing use of extended criteria donors (ECD) sets higher requirements
for graft preservation. Machine perfusion (MP) improves orthotopic liver transplantation …

Based on the renaissance of dynamic preservation techniques, extended criteria donor
(ECD) livers reclaimed a valuable eligibility in the transplantable organ pool. Being more …

Extracellular vesicles (EVs) are emerging as a promising field of research in liver disease.
EVs are small, membrane-bound vesicles that contain various bioactive molecules, such as …