The receptor tyrosine kinase MERTK is aberrantly expressed in numerous human
malignancies, and is a novel target in cancer therapeutics. Physiologic roles of MERTK …

Hepatic macrophages, the key cellular components of the liver, emerge as essential players
in liver inflammation, tissue repair and subsequent fibrosis, as well as tumorigenesis …

Background & Aims Activation of Kupffer cells and recruitment of monocytes are key events
in fibrogenesis. These cells release soluble mediators which induce the activation of hepatic …

Myeloid cells are increasingly recognized as major players in transplant rejection. Here, we
used a murine kidney transplantation model and single cell transcriptomics to dissect the …

Innovative approaches in nanoparticle design have facilitated the creation of new
formulations of nanoparticles that are capable of selectively calibrating the immune …

Chondroitin sulfate proteoglycans (CSPGs) are fundamental components of the extracellular
matrix in the central nervous system (CNS). Among these, the Nerve-Glial antigen 2 (NG2) …

Objectives This study aimed to investigate the protective effect of SCARF1 on acute rejection
(AR), phagocytic clearance of Kupffer cells (KCs), M2 polarization and the exact mechanism …

Macrophage is an important innate immune cell that not only initiates inflammatory
responses, but also functions in tissue repair and anti-inflammatory responses. Regulating …

Recipients of solid organ transplantation (SOT) rely on life-long immunosuppression (IS),
which is associated with significant side effects. Extracorporeal photochemotherapy (ECP) is …

Recently, efforts have been made to recognize the precise reason (s) for transplant failure
and the process of rejection utilizing the molecular signature. Most transplant recipients do …