Direct-acting antivirals for RSV treatment, a review

B Bonneux, E Jacoby, M Ceconi, K Stobbelaar… - Antiviral Research, 2024 - Elsevier
Respiratory syncytial virus (RSV) causes respiratory disease and complications in infants,
the elderly and the immunocompromised. While three vaccines and two prophylactic …

Recent progress toward the discovery of small molecules as novel anti-respiratory syncytial virus agents

T Felicetti, C Sarnari, R Gaito, O Tabarrini… - Journal of Medicinal …, 2024 - ACS Publications
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …

Structure of the Nipah virus polymerase phosphoprotein complex

G Yang, D Wang, B Liu - Nature communications, 2024 - nature.com
Abstract The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its
high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large …

Structural and functional analysis of the Nipah virus polymerase complex

S Hu, H Kim, P Yang, Z Yu, B Ludeke, S Mobilia, J Pan… - Cell, 2025 - cell.com
Nipah virus (NiV) is a bat-borne, zoonotic RNA virus that is highly pathogenic in humans.
The NiV polymerase, which mediates viral genome replication and mRNA transcription, is a …

Discovery of gem-Dimethyl-hydroxymethylpyridine Derivatives as Potent Non-nucleoside RSV Polymerase Inhibitors

S Grosse, L Cooymans, W Embrechts… - Journal of medicinal …, 2024 - ACS Publications
Respiratory syncytial virus (RSV) is an RNA virus infecting the upper and lower respiratory
tract and is recognized as a major respiratory health threat, particularly to older adults …

Structural basis of paramyxo-and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals

JD Wolf, MR Sirrine, RM Cox… - Antimicrobial Agents and …, 2024 - journals.asm.org
Small-molecule antivirals can be used as chemical probes to stabilize transitory
conformational stages of viral target proteins, facilitating structural analyses. Here, we …

Structural basis for dimerization of a paramyxovirus polymerase complex

J Xie, M Ouizougun-Oubari, L Wang, G Zhai… - Nature …, 2024 - nature.com
The transcription and replication processes of non-segmented, negative-strand RNA viruses
(nsNSVs) are catalyzed by a multi-functional polymerase complex composed of the large …

How does the polymerase of non-segmented negative strand RNA viruses commit to transcription or genome replication?

VA Kleiner, R Fearns - Journal of Virology, 2024 - journals.asm.org
The Mononegavirales, or non-segmented negative-sense RNA viruses (nsNSVs), includes
significant human pathogens, such as respiratory syncytial virus, parainfluenza virus …

Structure–Activity Relationship of Oxacyclo-and Triazolo-Containing Respiratory Syncytial Virus Polymerase Inhibitors

MT Tran, S Grosse, RJ Carbajo, E Jacoby… - ACS Medicinal …, 2024 - ACS Publications
Despite the availability of medicines preventing respiratory syncytial virus (RSV) infection,
post-exposure treatment options are needed for addressing patient's needs. RSV non …

[HTML][HTML] Evaluation of a non-nucleoside inhibitor of the RSV RNA-dependent RNA polymerase in translatable animal models

MP Citron, X Zang, A Leithead, S Meng, WA Rose II… - Journal of Infection, 2024 - Elsevier
Summary Respiratory Syncytial Virus (RSV) causes severe respiratory infections and
concomitant disease resulting in significant morbidity and mortality in infants, elderly, and …