[HTML][HTML] The contact activation and kallikrein/kinin systems: pathophysiologic and physiologic activities

AH Schmaier - Journal of Thrombosis and Haemostasis, 2016 - Elsevier
The contact activation system (CAS) and kallikrein/kinin system (KKS) are older recognized
biochemical pathways that include several proteins that skirt the fringes of the blood …

The dipeptidyl peptidase family, prolyl oligopeptidase, and prolyl carboxypeptidase in the immune system and inflammatory disease, including atherosclerosis

Y Waumans, L Baerts, K Kehoe, AM Lambeir… - Frontiers in …, 2015 - frontiersin.org
Research from over the past 20 years has implicated dipeptidyl peptidase (DPP) IV and its
family members in many processes and different pathologies of the immune system. Most …

Microanatomy of the human atherosclerotic plaque by single-cell transcriptomics

MAC Depuydt, KHM Prange, L Slenders, T Örd… - Circulation …, 2020 - Am Heart Assoc
Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension

D Saygin, T Tabib, HET Bittar, E Valenzi… - Pulmonary …, 2020 - journals.sagepub.com
Despite recent improvements in management of idiopathic pulmonary arterial hypertension,
mortality remains high. Understanding the alterations in the transcriptome–phenotype of the …

ACE2 in the renin–angiotensin system

T Verano-Braga, ALV Martins, D Motta-Santos… - Clinical …, 2020 - portlandpress.com
In 2020 we are celebrating the 20th anniversary of the angiotensin-converting enzyme 2
(ACE2) discovery. This event was a landmark that shaped the way that we see the renin …

Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius

JA Rosenfeld, D Reeves, MR Brugler… - Nature …, 2016 - nature.com
The common bed bug (Cimex lectularius) has been a persistent pest of humans for
thousands of years, yet the genetic basis of the bed bug's basic biology and adaptation to …

The spike effect of acute respiratory syndrome coronavirus 2 and coronavirus disease 2019 vaccines on blood pressure

F Angeli, M Zappa, G Reboldi, G Gentile… - European Journal of …, 2023 - Elsevier
Among the various comorbidities potentially worsening the clinical outcome in patients
hospitalized for the acute respiratory syndrome coronavirus-2 (SARS-CoV-2), hypertension …

COVID-19, vaccines and deficiency of ACE2 and other angiotensinases. Closing the loop on the" Spike effect"

F Angeli, G Reboldi, M Trapasso, M Zappa… - European journal of …, 2022 - Elsevier
The role of a dysregulated renin-angiotensin system (RAS) in the pathogenesis of COVID-19
is well recognized. The imbalance between angiotensin II (Ang II) and Angiotensin 1-7 (Ang …

Hypothermic pulsatile perfusion of human pancreas: preliminary technical feasibility study based on histology

J Branchereau, K Renaudin, D Kervella, S Bernadet… - Cryobiology, 2018 - Elsevier
Background There are currently two approaches to hypothermic preservation for most solid
organs: static or dynamic. Cold storage is the main method used for static storage (SS) …

Genetic adaptations of the plateau zokor in high-elevation burrows

Y Shao, JX Li, RL Ge, L Zhong, DM Irwin… - Scientific Reports, 2015 - nature.com
The plateau zokor (Myospalax baileyi) spends its entire life underground in sealed burrows.
Confronting limited oxygen and high carbon dioxide concentrations and complete darkness …