Effects of intermittent fasting on health, aging, and disease

R De Cabo, MP Mattson - New England Journal of Medicine, 2019 - Mass Medical Soc
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a
6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to …

Interventions to slow aging in humans: are we ready?

VD Longo, A Antebi, A Bartke, N Barzilai… - Aging cell, 2015 - Wiley Online Library
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression

M Weng, W Chen, X Chen, H Lu, Z Sun, Q Yu… - Nature …, 2020 - nature.com
Evidence suggests that fasting exerts extensive antitumor effects in various cancers,
including colorectal cancer (CRC). However, the mechanism behind this response is …

Endogenous hydrogen sulfide production is essential for dietary restriction benefits

C Hine, E Harputlugil, Y Zhang, C Ruckenstuhl, BC Lee… - Cell, 2015 - cell.com
Dietary restriction (DR) without malnutrition encompasses numerous regimens with
overlapping benefits including longevity and stress resistance, but unifying nutritional and …

Intermittent fasting: potential utility in the treatment of chronic pain across the clinical spectrum

JP Caron, MA Kreher, AM Mickle, S Wu, R Przkora… - Nutrients, 2022 - mdpi.com
Dietary behavior can have a consequential and wide-ranging influence on human health.
Intermittent fasting, which involves intermittent restriction in energy intake, has been shown …

[HTML][HTML] Protein and calorie restriction contribute additively to protection from renal ischemia reperfusion injury partly via leptin reduction in male mice

LT Robertson, JH Trevino-Villarreal, P Mejia… - The Journal of …, 2015 - Elsevier
Background: Short-term dietary restriction (DR) without malnutrition preconditions against
surgical stress in rodents; however, the nutritional basis and underlying nutrient/energy …

Current knowledge about the effect of nutritional status, supplemented nutrition diet, and gut microbiota on hepatic ischemia-reperfusion and regeneration in liver …

ME Cornide-Petronio, AI Álvarez-Mercado… - Nutrients, 2020 - mdpi.com
Ischemia-reperfusion (I/R) injury is an unresolved problem in liver resection and
transplantation. The preexisting nutritional status related to the gut microbial profile might …

Signaling network of forkhead family of transcription factors (FOXO) in dietary restriction

Y Jiang, F Yan, Z Feng, P Lazarovici, W Zheng - Cells, 2019 - mdpi.com
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake
without causing malnutrition, has been proved to be a robust way to extend both lifespan …

[HTML][HTML] Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5–dependent and–independent mechanisms

JH Treviño-Villarreal, JS Reynolds, A Bartelt… - JCI insight, 2018 - ncbi.nlm.nih.gov
Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Dietary
interventions based on protein restriction (PR) reduce circulating triglycerides (TGs), but …

Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice

P Kip, TJ Sluiter, MR MacArthur, M Tao, N Kruit… - Nature …, 2024 - nature.com
Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to
mitigate surgical injury response. However, its application to improve post-interventional …