The glycine betaine role in neurodegenerative, cardiovascular, hepatic, and renal diseases: Insights into disease and dysfunction networks

JA Rosas-Rodríguez, EM Valenzuela-Soto - Life sciences, 2021 - Elsevier
Abstract Glycine betaine (N, N, N-trimethyl amine) is an osmolyte accumulated in cells that is
key for cell volume and turgor regulation, is the principal methyl donor in the methionine …

[HTML][HTML] Osmoprotective functions conferred to soybean plants via inoculation with Sphingomonas sp. LK11 and exogenous trehalose

S Asaf, AL Khan, MA Khan, QM Imran, BW Yun… - Microbiological …, 2017 - Elsevier
Osmotic stress induced by drought can hinder the growth and yield of crop plants. To
understand the eco-physiological role of osmoprotectants, the combined utilization of …

Changing relations between proteins and osmolytes: a choice of nature

A Rani, P Venkatesu - Physical Chemistry Chemical Physics, 2018 - pubs.rsc.org
Many studies aimed at advancing our understanding of the mechanisms of protein
stabilization that support the survival of organisms under harsh environmental conditions are …

An overview of betaine supplementation, sports performance, and body composition

JM Cholewa, DE Newmire, FE Rossi… - Nutrition and Enhanced …, 2019 - Elsevier
Trimethylglycine (betaine) serves three major roles in mammal physiology:(1) a major
osmolyte that accumulates in most tissues and assists in cell volume regulation,(2) a …

Combined action of chemical chaperones on stability, aggregation and oligomeric state of muscle glycogen phosphorylase b

TB Eronina, VV Mikhaylova, NA Chebotareva… - International Journal of …, 2022 - Elsevier
Chemical chaperones are a class of small molecules, which enhance protein stability,
folding, inhibit protein aggregation, and are used for long-term storage of therapeutic …

Can glycine betaine denature proteins?

A Acharyya, D Shin, T Troxler, F Gai - Physical Chemistry Chemical …, 2020 - pubs.rsc.org
Glycine betaine (GB) is a naturally occurring osmolyte that has been widely recognized as a
protein protectant. Since GB consists of a methylated ammonium moiety, it can engage in …

Effects of osmolytes under crowding conditions on the properties of muscle glycogen phosphorylase b

VV Mikhaylova, TB Eronina - Biochimie, 2024 - Elsevier
The study of the relationship between the activity and stability of enzymes under crowding
conditions in the presence of osmolytes is important for understanding the functioning of a …

Amino acids and glycine derivatives differently affect refolding of mesophilic and thermophilic like α-amylases: implications in protein refolding and aggregation

A Ahmad, P Joshi, R Mishra - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Abstract α-amylases are industrially important enzymes which are used in different starch-
based industries. They are adapted to different environmental conditions like extremes of …

Protein Folding Pathways in the Presence of Osmolytes

A Mohan, V Puppala, I Roy - … From Chaperoning Protein Folding to Clinical …, 2024 - Springer
The mechanism of how and why proteins fold is not understood very well. However, the
importance of folded proteins cannot be overemphasized. Their role in maintaining and …

Glycine betaine as a major osmolyte under abiotic stress in halophytes

SA Siddiqui, A Kumari, MS Rathore - Handbook of Halophytes: From …, 2021 - Springer
Among different organic solutes, glycine betaine (GB) is an important compatible solute
under stress condition. It performs different functions, and under stressed environment, its …