Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders

WS Blaner - Pharmacology & therapeutics, 2019 - Elsevier
Much evidence has accumulated in the literature over the last fifteen years that indicates
vitamin A has a role in metabolic disease prevention and causation. This literature proposes …

Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies

ML Bonet, J Ribot, S Galmés, F Serra… - Biochimica et Biophysica …, 2020 - Elsevier
Antiobesity activities of carotenoids and carotenoid conversion products (CCPs) have been
demonstrated in pre-clinical studies, and mechanisms behind have begun to be unveiled …

Retinoic acid signaling in development and differentiation commitment and its regulatory topology

D Wu, FA Khan, K Zhang, NS Pandupuspitasari… - Chemico-Biological …, 2024 - Elsevier
Retinoic acid (RA), the derivative of vitamin A/retinol, is a signaling molecule with important
implications in health and disease. It is a well-known developmental morphogen that …

Increasing adipocyte number and reducing adipocyte size: the role of retinoids in adipose tissue development and metabolism

B Wang, M Du - Critical Reviews in Food Science and Nutrition, 2024 - Taylor & Francis
The rising prevalence of obesity is a grave public health threat. In response to excessive
energy intake, adipocyte hypertrophy impairs cellular function and leads to metabolic …

Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors

B Wang, X Fu, X Liang, JM Deavila, Z Wang, L Zhao… - Cell discovery, 2017 - nature.com
Formation of beige adipocytes within white adipose tissue enhances energy expenditure,
which is a promising strategy to reduce obesity and prevent metabolic symptoms. Vitamin A …

Growth arrest and DNA damage‐inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha

W You, S Liu, J Ji, D Ling, Y Tu, Y Zhou… - Journal of Cachexia …, 2023 - Wiley Online Library
Background Skeletal muscle fat infiltration is a common feature during ageing, obesity and
several myopathies associated with muscular dysfunction and sarcopenia. However, the …

[HTML][HTML] Effect of vitamin A injection at birth on intramuscular fat development and meat quality in beef cattle

FC Maciel, ORM Neto, MS Duarte, M Du, JF Lage… - Meat Science, 2022 - Elsevier
This study aimed to evaluate intramuscular fat and expression of genes in the muscle of
Montana× Nellore treated with vitamin A at birth. We hypothesized that an injection of …

Neonatal vitamin A administration increases intramuscular fat by promoting angiogenesis and preadipocyte formation

X Yu, Y Ma, Y Luo, G Tang, Z Jiang, J Zhang, B Ye… - Meat Science, 2022 - Elsevier
To explore the effects and underlying mechanism of vitamin A on beef marbling fat
development, angus steers were injected vitamin A at birth and 1 month of age and in vitro …

Intermuscular adipose tissue in obesity and related disorders: cellular origins, biological characteristics and regulatory mechanisms

T Zhang, J Li, X Li, Y Liu - Frontiers in Endocrinology, 2023 - frontiersin.org
Intermuscular adipose tissue (IMAT) is a unique adipose depot interspersed between
muscle fibers (myofibers) or muscle groups. Numerous studies have shown that IMAT is …

GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1

W You, S Liu, J Li, Y Tu, T Shan - BMC biology, 2023 - Springer
Background Obesity, characterized by excessive white adipose tissue expansion, is
associated with several metabolic complications. Identifying new adipogenesis regulators …