Bridging the translational gap: what can synaptopathies tell us about autism?

CJ Molloy, J Cooke, NJF Gatford… - Frontiers in Molecular …, 2023 - frontiersin.org
Multiple molecular pathways and cellular processes have been implicated in the
neurobiology of autism and other neurodevelopmental conditions. There is a current focus …

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice

E Atanasova, AP Arévalo, I Graf, R Zhang, J Bockmann… - Molecular Autism, 2023 - Springer
Background Autism spectrum disorder (ASD) is mainly characterized by deficits in social
interaction and communication and repetitive behaviors. Known causes of ASD are …

Excessive self-grooming, gene dysregulation and imbalance between the striosome and matrix compartments in the striatum of Shank3 mutant mice

AT Ferhat, E Verpy, A Biton, B Forget… - Frontiers in molecular …, 2023 - frontiersin.org
Autism is characterized by atypical social communication and stereotyped behaviors.
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are detected in 1 …

The influence of Shank3 deletion and maternal immune activation on the development of an autistic phenotype

E Atanasova - 2023 - oparu.uni-ulm.de
Autism spectrum disorders (ASDs) are neurodevelopmental disorders with two main
symptoms–alterations in social behaviour and communication and in repetitive behaviours …