Apolipoprotein (apo) E is a multifunctional protein with central roles in lipid metabolism,
neurobiology, and neurodegenerative diseases. It has three major isoforms (apoE2, apoE3 …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

Inheritance of apolipoprotein E4 (APOE4) is a major risk factor for development of
Alzheimer's disease (AD). This lipoprotein, in contrast to apoE2, has arginine residues at …

The LDL receptor–related protein (LRP) is larger than but structurally similar to other
members of the LDL receptor gene family, an ancient family of endocytic receptors (1–3) …

A hallmark of all forms of Alzheimer's disease (AD) is an abnormal accumulation of the β-
amyloid protein (Aβ) in specific brain regions. Both the generation and clearance of Aβ are …

The low-density lipoprotein receptor–related protein (Lrp)-5 functions as a Wnt coreceptor.
Here we show that mice with a targeted disruption of Lrp5 develop a low bone mass …

Two apolipoprotein E (apoE) receptors, the very low density lipoprotein (VLDL) receptor and
apoE receptor 2 (apoER2), are also receptors for Reelin, a signaling protein that regulates …

Cholesterol is a multifacetted molecule. First, it serves as an essential membrane
component, as a cofactor for signaling molecules and as a precursor for steroid hormones; …

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease. However,
the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice had …

Apolipoprotein E (apoE) is found in amyloid plaques and neurofibrillary tangles (NFTs) in
Alzheimer's disease (AD) brains, but its role in their pathogenesis is unclear. Previously, we …