Therapeutic vaccines for tuberculosis: an overview
R Bouzeyen, B Javid - Frontiers in Immunology, 2022 - frontiersin.org
Tuberculosis (TB), caused by Mycobacterium tuberculosis is the world's deadliest bacterial
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …
infection, resulting in more than 1.4 million deaths annually. The emergence of drug …
Next-generation TB vaccines: progress, challenges, and prospects
L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …
infectious disease and a leading cause of mortality worldwide. Currently, the only available …
The success and failure of BCG—implications for a novel tuberculosis vaccine
P Andersen, TM Doherty - Nature Reviews Microbiology, 2005 - nature.com
Over the past 50 years, the Mycobacterium bovis bacille Calmette–Guérin (BCG) vaccine
against tuberculosis (TB) has maintained its position as the world's most widely used …
against tuberculosis (TB) has maintained its position as the world's most widely used …
Tuberculosis: what we don't know can, and does, hurt us
Mycobacterium tuberculosis has a penetrance of its host population that would be the envy
of most human pathogens. About one-third of the human population would have a positive …
of most human pathogens. About one-third of the human population would have a positive …
Construction, characterization and preclinical evaluation of MTBVAC, the first live-attenuated M. tuberculosis-based vaccine to enter clinical trials
A Arbues, JI Aguilo, J Gonzalo-Asensio, D Marinova… - Vaccine, 2013 - Elsevier
The development of a new tuberculosis vaccine is an urgent need due to the failure of the
current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an …
current vaccine, BCG, to protect against the respiratory form of the disease. MTBVAC is an …
Molecular epidemiology of tuberculosis: current insights
Molecular epidemiologic studies of tuberculosis (TB) have focused largely on utilizing
molecular techniques to address short-and long-term epidemiologic questions, such as in …
molecular techniques to address short-and long-term epidemiologic questions, such as in …
Mucosal resident memory CD4 T cells in protection and immunopathology
Tissue-resident memory T cells (TRM) comprise a newly defined subset, which comprises a
major component of lymphocyte populations in diverse peripheral tissue sites, including …
major component of lymphocyte populations in diverse peripheral tissue sites, including …
Next-generation vaccines based on Bacille Calmette–Guérin
NE Nieuwenhuizen, SHE Kaufmann - Frontiers in immunology, 2018 - frontiersin.org
Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis (Mtb),
remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette …
remains a major health threat. A live, attenuated mycobacterium known as Bacille Calmette …
Influence of BCG vaccine strain on the immune response and protection against tuberculosis
Abstract The Bacille Calmette–Guérin (BCG) vaccine has been used for more than 80 years
to protect against tuberculosis. Worldwide, over 90% of children are immunized with BCG …
to protect against tuberculosis. Worldwide, over 90% of children are immunized with BCG …
Viral Booster Vaccines Improve Mycobacterium bovis BCG-Induced Protection against Bovine Tuberculosis
HM Vordermeier, B Villarreal-Ramos… - Infection and …, 2009 - Am Soc Microbiol
Previous work with small-animal laboratory models of tuberculosis has shown that
vaccination strategies based on heterologous prime-boost protocols using Mycobacterium …
vaccination strategies based on heterologous prime-boost protocols using Mycobacterium …