Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology …

C Antoniades, D Tousoulis, M Vavlukis… - European heart …, 2023 - academic.oup.com
Obesity is a modifiable cardiovascular risk factor, but adipose tissue (AT) depots in humans
are anatomically, histologically, and functionally heterogeneous. For example, visceral AT is …

[HTML][HTML] Perivascular adipose tissue: Fine-tuner of vascular redox status and inflammation

CK Cheng, H Ding, M Jiang, H Yin, M Gollasch… - Redox Biology, 2023 - Elsevier
Perivascular adipose tissue (PVAT) refers to the aggregate of adipose tissue surrounding
the vasculature, exhibiting the phenotypes of white, beige and brown adipocytes. PVAT has …

The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall

C Hillock-Watling, AI Gotlieb - Cardiovascular Pathology, 2022 - Elsevier
The perivascular adipose tissue (PVAT) is an adipose tissue depot which surrounds most
human blood vessels. It is metabolically active and has both a protective and a pathogenic …

Perivascular adipose tissue and vascular smooth muscle tone: friends or foes?

A Ahmed, A Bibi, M Valoti, F Fusi - Cells, 2023 - mdpi.com
Perivascular adipose tissue (PVAT) is a specialized type of adipose tissue that surrounds
most mammalian blood vessels. PVAT is a metabolically active, endocrine organ capable of …

Secretome of adipose tissue as the key to understanding the endocrine function of adipose tissue

D Pogodziński, L Ostrowska… - International journal of …, 2022 - mdpi.com
The prevalence of obesity has reached pandemic levels and is becoming a serious health
problem in developed and developing countries. Obesity is associated with an increased …

Adipokines in atherosclerosis: unraveling complex roles

J Luo, Z He, Q Li, M Lv, Y Cai, W Ke, X Niu… - Frontiers in …, 2023 - frontiersin.org
Adipokines are biologically active factors secreted by adipose tissue that act on local and
distant tissues through autocrine, paracrine, and endocrine mechanisms. However …

Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL‐6/STAT3‐associated immune phenotypes in pancreatic cancer

K Aliar, HR Waterhouse, F Vyas, N Krebs… - The Journal of …, 2023 - Wiley Online Library
Integration and mining of bioimaging data remains a challenge and lags behind the rapidly
expanding digital pathology field. We introduce Hourglass, an open‐access analytical …

Phenotypic and functional disparities in perivascular adipose tissue

E Guo, D Liu, Z Zhu - Frontiers in Physiology, 2024 - frontiersin.org
The adipose tissue surrounding blood vessels is known as perivascular adipose tissue
(PVAT), which represents a distinct ectopic fat depot that adheres to the majority of the …

Direct oral and fiber-derived butyrate supplementation as an anti-obesity treatment via different targets

Z Majka, B Zapala, A Krawczyk, K Czamara… - Clinical Nutrition, 2024 - Elsevier
Summary Background & Aims Butyrate (one of the short-chain fatty acids), a major byproduct
of the fermentation of non-digestible carbohydrates (eg fiber), is supposed to have anti …

Reactive oxygen species are central mediators of vascular dysfunction and hypertension induced by ethanol consumption

JC Padovan, TMH Dourado, GF Pimenta… - Antioxidants, 2023 - mdpi.com
Consumption of high amounts of ethanol is a risk factor for development of cardiovascular
diseases such as arterial hypertension. The hypertensive state induced by ethanol is a …