The immune system is generally known to be the primary defense mechanism against
pathogens. Any pathological conditions are reflected in anomalies in the immune system …

Schizophrenia has been an evolutionary paradox: it has high heritability, but it is associated
with decreased reproductive success. The causal genetic variants underlying schizophrenia …

Microbiome data predictive analysis within a machine learning (ML) workflow presents
numerous domain-specific challenges involving preprocessing, feature selection, predictive …

BackgroundAccumulating evidence suggests that positive and negative emotions, as well as
emotion regulation, play key roles in human health and disease. Recent work has shown the …

Balanced fear supports human rational decision-making and useful behavioral responses.
In contrast, overwhelming, persistent, and unbalanced fear can paralyze the individual and …

Background Numerous studies report gut microbiome variations in bipolar disorder (BD) and
schizophrenia spectrum disorders (SSD) compared to healthy individuals, though, there is …

The prevalence of schizophrenia, affecting approximately 1% of the global population,
underscores the urgency for innovative therapeutic strategies. Recent insights into the role …

Abstract Background and Hypothesis Antipsychotics (APs), the cornerstone of schizophrenia
treatment, confer a relatively high risk of constipation. However, the mechanisms …

Excessive predominance of pathological species in the gut microbiota could increase the
production of inflammatory mediators at the gut level and, via modification of the gut–blood …

Background Altered intestinal permeability and low-grade chronic inflammation disrupt the
integrity of the blood–brain barrier (microbiota–gut–brain axis), probably playing a role in the …