Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …

Conspectus Compounds containing a difluoromethylene unit have gained increasing
attention due to their utility in drug design. Classic methods for the synthesis of these …

Currently, the chemistry of organofluorine compounds is a leading and rapidly developing
area of organic chemistry. Fluorine present in a molecule largely determines its specific …

Difluorocarbene is a versatile, reactive intermediate for use in organic synthesis. Over the
past decade, significant progress has been made in difluorocarbene chemistry owing to the …

Selective incorporation of fluorine atoms or fluorinated moieties into organic molecules has
become a routine and powerful strategy in drug design and new functional-material …

Molecules bearing fluorine are increasingly prevalent in pharmaceuticals, agrochemicals,
and functional materials. The cyanodifluoromethyl group is unique because its size is closer …

The challenges of the modern society and the growing demand of high-technology sectors
of industrial production bring about a new phase in the development of organic synthesis. A …

A transition‐metal‐free difluoromethylenation of diazo compounds that proceeds under mild
conditions has been developed and is based on the use of TMSCF2Br as the …

Conspectus As fluorine has played an increasingly important role in modulating the
physical, chemical, and biological properties of organic molecules, the selective introduction …

The study of transition-metal difluorocarbene complex has long been a subject of active
investigation, but the transition-metal-catalyzed transfer of difluorocarbene remains a …