Pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3) are
members of the nuclear receptor superfamily that mainly act as ligand-activated transcription …

Diabetic nephropathy is the main cause of end-stage renal disease. MicroRNAs are
powerful regulators of the genome, and global expression profiling revealed miR-21 to be …

Type I innate lymphoid cells (ILC1s) are critical regulators of inflammation and immunity in
mammalian tissues. However, their function in cancer is mostly undefined. Here, we show …

LSD1 has emerged as a promising epigenetic target in the treatment of acute myeloid
leukemia (AML). We used two murine AML models based on retroviral overexpression of …

JMJD3, a stress-inducible H3K27 demethylase, plays a critical regulatory role in the
initiation and progression of malignant hematopoiesis. However, how this histone modifier …

Aims Cardiac transplantation is the only curative therapy for end-stage heart failure. Fibrosis
is one of the major causes for impaired function of cardiac allografts. MicroRNAs, a class of …

Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8
was originally identified as an essentialfactor for myeloid cell lineage commitment and …

Identifying novel cell surface receptors that regulate leukemia cell differentiation and can be
targeted to inhibit cellular proliferation is crucial to improve current treatment modalities in …

Simple Summary Despite progress, acute myeloid leukemia (AML) remains one of the
deadliest cancer diseases. The identification of novel molecular targets may allow …

Relapse of acute myeloid leukemia (AML) after allogeneic bone marrow transplantation has
been linked to immune evasion due to reduced expression of major histocompatibility …