Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct
morphological features and clinical behaviors. Although morphology is often associated with …

Breast cancer is a heterogeneous disease that encompasses several distinct entities with
remarkably different biological characteristics and clinical behaviour. Currently, breast …

Background Although numerous mouse models of breast carcinomas have been developed,
we do not know the extent to which any faithfully represent clinically significant human …

Gene amplification is a copy number increase of a restricted region of a chromosome arm. It
is prevalent in some tumors and is associated with overexpression of the amplified gene (s) …

Breast cancers arising in germline carriers of BRCA1 mutations have a characteristic
phenotype that has been shown in many studies to differentiate BRCA1 tumours from …

Background Hereditary breast cancer runs in families where several members in different
generations are affected. Most of these breast cancers are caused by mutations in the high …

Purpose: Basal-like phenotype tumors are frequently found among BRCA1 germ-line
mutated breast carcinomas. They are biologically aggressive and have a tendency towards …

Abstract Background The SRY-related HMG-box family of transcription factors member
SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural …

Abstract Poly (ADP‐ribose) polymerase (PARP) is an attractive antitumor target because of
its vital role in DNA repair. The homologous recombination (HR) DNA repair pathway is …

Tumours arising in BRCA1 mutation carriers and sporadic basal-like breast carcinomas
have similar phenotypic, immunohistochemical and clinical characteristics. SOX2 is an …