Brain mitochondrial bioenergetics in genetic neurodevelopmental disorders: focus on Down, Rett and fragile X syndromes
Mitochondria, far beyond their prominent role as cellular powerhouses, are complex cellular
organelles active as central metabolic hubs that are capable of integrating and controlling …
organelles active as central metabolic hubs that are capable of integrating and controlling …
Mitochondrial dysfunction in Down syndrome: From pathology to therapy
Mitochondrial dysfunctions have been described in Down syndrome (DS) caused by either
partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various …
partial or full trisomy of chromosome 21 (HSA21). Mitochondria play a crucial role in various …
The implication of a diversity of non-neuronal cells in disorders affecting brain networks
M Carrier, K Dolhan, BC Bobotis… - Frontiers in Cellular …, 2022 - frontiersin.org
In the central nervous system (CNS) neurons are classically considered the functional unit of
the brain. Analysis of the physical connections and co-activation of neurons, referred to as …
the brain. Analysis of the physical connections and co-activation of neurons, referred to as …
Senescent hearts from male Ts65Dn mice exhibit preserved function but altered size and nicotinamide adenine dinucleotide pathway signaling
J Brandauer, CN Receno, C Anyaoku… - American Journal …, 2024 - journals.physiology.org
Down syndrome (DS) is associated with congenital heart defects at birth, but cardiac
function has not been assessed at older ages. We used the Ts65Dn mouse, a model of DS …
function has not been assessed at older ages. We used the Ts65Dn mouse, a model of DS …
Understanding perspectives and research trends in Down syndrome neuropathogenesis: A bibliometric analysis
T Huang, XJ Lam, CT Lim, N Jusoh… - Journal of …, 2024 - journals.sagepub.com
Down syndrome (DS), characterised by compromised brain development and intellectual
challenges, often manifests Alzheimer's disease (AD)-like symptoms. Utilising the Web of …
challenges, often manifests Alzheimer's disease (AD)-like symptoms. Utilising the Web of …