The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …

The mammalian gut is inhabited by a massive and complicated microbial community, in
which the host achieves a stable symbiotic environment through the interdependence …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

Metabolism and gene expression, which are two fundamental biological processes that are
essential to all living organisms, reciprocally regulate each other to maintain homeostasis …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain.
Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to …

Background Many metabolites serve as important signalling molecules to adjust cellular
activities and functions based on nutrient availability. Links between acetyl-CoA metabolism …

Packaging the long and fragile genomes of eukaryotic species into nucleosomes is all well
and good, but how do cells gain access to the DNA again after it has been bundled away …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …