Comprising the majority of leukocytes in humans, neutrophils are the first immune cells to
respond to inflammatory or infectious etiologies and are crucial participants in the proper …

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …

Hematopoietic stem cells (HSCs) are rare, multipotent cells that generate via progenitor and
precursor cells of all blood lineages. Similar to normal hematopoiesis, leukemia is also …

Research in the last decade has explored the length of telomeres, the protective ends of
eukaryotic chromosomes, as a biomarker for the cumulative effects of environmental …

Hematopoietic stem cells (HSCs) self-renew in bone marrow niches formed by
mesenchymal progenitors and endothelial cells expressing the chemokine CXCL12, but …

Long-lived plasma cells (PCs) in the bone marrow (BM) are a critical source of antibodies
after infection or vaccination, but questions remain about the factors that control PCs. We …

The spleen is a complex secondary lymphoid organ that plays a crucial role in controlling
blood-stage infection with Plasmodium parasites. It is tasked with sensing and removing …

Human immunodeficiency virus (HIV) eradication or long-term suppression in the absence
of antiretroviral therapy (ART) requires an understanding of all viral reservoirs that could …

Sepsis remains the single most common cause of mortality and morbidity in hospitalized
patients requiring intensive care. Although earlier detection and improved treatment bundles …

Emergency myelopoiesis (EM) is a hematopoietic response against systemic infections that
quickly supplies innate immune cells. As lymphopoiesis is strongly suppressed during EM …