Matrix metalloproteinases (MMPs) are a family of zinc-dependent extracellular matrix (ECM)
remodeling endopeptidases that have the capacity to degrade almost every component of …

Significance: Oxidative stress represents the common hallmark of pathological conditions
associated with cardiovascular disease (CVD), including atherosclerosis, heart failure …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

Over the past 50 years, steady growth in the field of metalloproteinase biology has shown
that the degradation of extracellular matrix components represents only a fraction of the …

OBJECTIVE: MicroRNAs are small non-coding RNAs that inversely regulate their target
gene expression. The whole miRNA profile of human atherosclerotic plaques has not been …

The SARS-CoV-2 hyperinflammatory response is associated with high mortality. This
hypothesis suggests that a deficiency of nicotinamide adenine dinucleotide (NAD+) may be …

Cardiovascular diseases can be considered the most important cause of death in diabetic
population and diabetes can in turn increase the risk of cardiovascular events. Inflammation …

A state of subclinical systemic inflammation is characteristically present in obesity/insulin
resistance and type 2 diabetes mellitus (T2DM). The aim of the study was to develop an …

OBJECTIVE Increased oxidative stress (OS) and impaired anti-OS defenses are important in
the development and persistence of insulin resistance (IR). Several anti-inflammatory and …

The sirtuins, silent mating-type information regulation 2 (SIRTs), are a family of nicotinamide
adenine dinucleotide (NAD+)-dependent histone deacetylases with important roles in …