The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

INTRODUCTION Variation in pigmentation among human populations may reflect local
adaptation to regional light environments, because dark skin is more photoprotective …

Hundreds of human genes are associated with neurological diseases, but translation into
tractable biological mechanisms is lagging. Larval zebrafish are an attractive model to …

Fish coloration, evolved from selection and adaptation, is a prominent feature of remarkable
aquaculture merits. Fish possess more pigment cell types than any other vertebrates and are …

The zebrafish Danio rerio, is an important model organism in developmental genetics,
neurophysiology and biomedicine, but little is known about its natural ecology and …

The introduction of engineered site-specific DNA endonucleases has brought precise
genome editing in many model organisms and human cells into the realm of possibility. In …

In a large-scale screen, we isolated mutants displaying a specific visible phenotype in
embryos or early larvae of the zebrafish, Danio rerio. Males were mutagenized with …

We report the isolation and identification of a new mutation affecting pigment cell fate in the
zebrafish neural crest. Homozygous nacre (nac w2) mutants lack melanophores throughout …

Zebrafish embryos and larvae have stage-specific patterns of motility or locomotion. Two
embryonic structures accomplish this behavior: the central nervous system (CNS) and …