The androgen receptor (AR) signaling axis drives all stages of prostate cancer, including the lethal, drug-resistant form of the disease termed castration-resistant prostate cancer (CRPC) …
T Ito, H Igarashi, H Uehara, MJ Berna, RT Jensen - Medicine, 2013 - journals.lww.com
Multiple endocrine neoplasia type 1 (MEN1) is classically characterized by the development of functional or nonfunctional hyperplasia or tumors in endocrine tissues (parathyroid …
JM De Laat, RB van der Luijt, CRC Pieterman… - BMC medicine, 2016 - Springer
Abstract Background Multiple Endocrine Neoplasia type 1 (MEN1) is diagnosed when two out of the three primary MEN1-associated endocrine tumors occur in a patient. Up to 10 …
Hypercalcitoninemia has frequently been reported as a marker for medullary thyroid carcinoma. Currently, calcitonin measurements are mostly useful in the evaluation of tumor …
CJ Yates, PJ Newey, RV Thakker - The Lancet Diabetes & …, 2015 - thelancet.com
Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder, is characterised by the occurrence of pancreatic neuroendocrine tumours (P-NETs) in …
A Falchetti - F1000Research, 2017 - ncbi.nlm.nih.gov
Despite its identification in 1997, the functions of the MEN1 gene—the main gene underlying multiple endocrine neoplasia type 1 syndrome—are not yet fully understood. In addition …
JM De Laat, CR Pieterman… - The Journal of …, 2014 - academic.oup.com
Context: The natural course and survival of neuroendocrine tumors (NETs) of thymus (Th) and lung in multiple endocrine neoplasia type 1 (MEN1) patients are still unknown …
Mutations of the multiple endocrine neoplasia type 1 (MEN1) gene lead to loss of function of its protein product menin. In keeping with its tumor suppressor function in endocrine tissues …
A Falchetti, F Marini, E Luzi, F Giusti, L Cavalli… - Genetics in …, 2009 - Elsevier
MEN 1 is a rare hereditary cancer syndrome which manifests a variety of endocrine and non- endocrine neoplasms and lesions. Growing knowledge of this condition in both its molecular …