The host response to biomaterials has been studied for decades. Largely, the interaction of
host immune cells, macrophages in particular, with implanted materials has been …

The foreign body reaction composed of macrophages and foreign body giant cells is the end-
stage response of the inflammatory and wound healing responses following implantation of …

Today, aseptic loosening is the most common cause of revision of major arthroplasties.
Aseptic loosening accounts for more than two-thirds of hip revisions and almost one-half of …

The osteolysis associated with conventional polyethylene on metal total joint replacements
is associated with the formation of an inflamed periprosthetic membrane rich in …

Joint arthroplasty had revolutionized the outcome of orthopaedic surgery. Extensive and
collaborative work of many innovator surgeons had led to the development of durable …

Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for
bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone …

We studied the effects of antibiotic prophylaxis, systemically and in bone cement, on the
revision rate of cemented total hip arthroplasties (THAs) in data from the Norwegian …

In the laboratory environment where biomaterials are synthesized and their biocompatibility
assessed, we find that endotoxin contamination is hard to avoid and must not be ignored. In …

The generation of wear debris is an inevitable result of normal usage of joint replacements.
Wear debris particles stimulate local and systemic biological reactions resulting in chronic …

Diagnosis of Periprosthetic Infection : JBJS Diagnosis of Periprosthetic Infection : JBJS
JBJS Journal Case Connector Reviews JBJS.org Surgical Techniques Open Access JOPA …