Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular
components and recycles metabolic substrates. In response to stress signals in the tumour …

Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Autophagy allows for cellular material to be delivered to lysosomes for degradation resulting
in basal or stress-induced turnover of cell components that provide energy and …

Autophagy is a mechanism by which cellular material is delivered to lysosomes for
degradation, leading to the basal turnover of cell components and providing energy and …

Autophagy is a conserved, self‐degradation system that is critical for maintaining cellular
homeostasis during stress conditions. Dysregulated autophagy has implications in health …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Autophagy is an essential cellular mechanism which plays “housekeeping” role in normal
physiological processes including removing of long lived, aggregated and misfolded …

Macroautophagy (referred to here as autophagy) is induced by starvation to capture and
degrade intracellular proteins and organelles in lysosomes, which recycles intracellular …

Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells,
such a homeostatic activity constitutes a robust barrier against malignant transformation …