RNA repair: hiding in plain sight
S Shuman - Annual Review of Genetics, 2023 - annualreviews.org
Enzymes that phosphorylate, dephosphorylate, and ligate RNA 5′ and 3′ ends were
discovered more than half a century ago and were eventually shown to repair purposeful …
discovered more than half a century ago and were eventually shown to repair purposeful …
Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archease
JL Gerber, SI Morales Guzmán, L Worf… - Nature …, 2024 - nature.com
RNA ligases of the RTCB-type play an essential role in tRNA splicing, the unfolded protein
response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA …
response and RNA repair. RTCB is the catalytic subunit of the pentameric human tRNA …
Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex
D Jaksch, J Irnstorfer, PF Kalman, J Martinez - RNA, 2023 - rnajournal.cshlp.org
The mammalian tRNA ligase complex (tRNA-LC) catalyzes the splicing of intron-containing
pre-tRNAs in the nucleus and the splicing of XBP1 mRNA during the unfolded protein …
pre-tRNAs in the nucleus and the splicing of XBP1 mRNA during the unfolded protein …