A 47-year-old woman with a history of breast cancer presents with confusion and
dehydration. The serum calcium level is 18.0 mg per deciliter. She has postural hypotension …

The geminal bisphosphonates are a new class of drugs characterised by a PCP bond.
Consequently, they are analogues of pyrophosphate, but are resistant to chemical and …

Study Objective: To review the effects of antihypercalcemic treatment on morbidity and
mortality in cancer-associated hypercalcemia. Design: Retrospective study of 126 …

PURPOSE Osteolytic metastases often give rise to hypercalcemia, fracture, and bone pain,
and occur commonly in patients with recurrent breast cancer. We assessed the …

PURPOSE The purpose of this article is to review the recent data on bisphosphonate use in
oncology and to provide some guidelines on the indications for their use in cancer patients …

The bisphosphonates comprise a new class of drugs, and are increasingly being used to
treat bone diseases characterised by increased osteoclastic bone resorption. These …

The efficacy of calcium (Ca) in reducing bone loss is debated. In a randomized placebo-
controlled double-masked study, we investigated the effects of oral Ca supplements on …

Abstract Osteoblast activity and plasma 1, 25 (OH) 2vitamin D are increased in HPT but
suppressed in HHM. To model HPT and HHM, we directly compared multiday continuous …

Three intravenous bisphosphonates were compared in the treatment of cancer-associated
hypercalcaemia. 48 patients were randomly allocated to one of three treatment groups (each …

Abstract Amino-bisphosphonates (N-BPs) have been commercially available for over four
decades and are used for the treatment of osteoporosis, Paget's disease, hypercalcemia of …