PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Globally,∼ 850 million individuals suffer from some form of kidney disease. This staggering
figure underscores the importance of continued research and innovation in the field of …

PLK1 is a key serine/threonine kinase as well as a master mitotic regulator, but it has never
been reported that PLK1 regulates DNA methylation. In the present study, we for the first …

As an outcome of chronic liver disease, liver fibrosis involves the activation of hepatic
stellate cells (HSCs) caused by a variety of chronic liver injuries. It is important to explore …

Nucleotide-binding oligomerization domain 2 (NOD2) is an immune sensor crucial for
eliciting the innate immune responses. Nevertheless, discrepancies exist regarding the …

As a highly conserved and ubiquitously expressed serine/threonine kinase, p21-activated
kinase 2 (PAK2) participates in diverse biologic events. However, its roles in mouse oocyte …

Breast cancer (Bca) remains the most common form of malignancy affecting females in
China, leading to significant reductions in the mental and physical health of those with this …

Colorectal cancer (CRC) is associated with numerous genetic disorders and cellular
abnormalities, and liver metastasis is a common health concern in patients with CRC …

The ubiquitin system is a dynamic regulatory pathway controlling the activity, subcellular
localization and stability of a myriad of cellular proteins, which in turn affects cellular …

Pulmonary hypertension is a rare disease with high morbidity and mortality which mainly
affects women of reproductive age. Despite recent advances in understanding the …