An overview of the medicinally important plant type III PKS derived polyketides

R Bisht, A Bhattacharyya, A Shrivastava… - Frontiers in Plant …, 2021 - frontiersin.org
Plants produce interesting secondary metabolites that are a valuable source of both
medicines for human use, along with significant advantages for the manufacturer species …

How structural subtleties lead to molecular diversity for the type III polyketide synthases

H Morita, CP Wong, I Abe - Journal of Biological Chemistry, 2019 - ASBMB
Type III polyketide synthases (PKSs) produce an incredibly diverse group of plant
specialized metabolites with medical importance despite their structural simplicity compared …

Recent advances in the catalytic synthesis of 4-quinolones

C Shen, A Wang, J Xu, Z An, KY Loh, P Zhang, X Liu - Chem, 2019 - cell.com
The 4-quinolones and their analogs are a heterogeneous group of biologically active
compounds that have evolved in modern days to provide utilities at the forefront of antibiotic …

Biosynthesis of barley wax β-diketones: a type-III polyketide synthase condensing two fatty acyl units

Y Sun, A Ruiz Orduna, Z Zhang, SJ Feakins… - Nature …, 2023 - nature.com
The surface coatings of cereal plants are dominated by waxy β-diketones crucial for drought
resistance and, therefore, grain yield. Here, barley (Hordeum vulgare) wax analyses reveal …

Plant alkaloids: production, extraction, and potential therapeutic properties

AG Pereira, L Cassani, P Garcia-Oliveira… - … : From Nature, Through …, 2023 - Springer
Alkaloids are a type of secondary metabolites that can be found in different parts of plants.
This group of compounds is diverse and can be divided into nine subgroups: pyridine …

Biosynthesis of medicinally important plant metabolites by unusual type III polyketide synthases

I Abe - Journal of natural medicines, 2020 - Springer
Recent research progress on the “second generation” type III polyketide synthases is
summarized. This class of enzymes catalyzes unusual condensation chemistries of CoA …

Dual engineering of olivetolic acid cyclase and tetraketide synthase to generate longer alkyl-chain olivetolic acid analogs

YE Lee, Y Nakashima, T Kodama, X Chen… - Organic …, 2021 - ACS Publications
The therapeutic effects of Δ9-tetrahydrocannabinol (Δ9-THC) can be enhanced by
modifications of the pentyl moiety at C-3. The engineering of Cannabis sativa olivetolic acid …

Transcriptome and metabolome profiling of the medicinal plant Veratrum mengtzeanum reveal key components of the alkaloid biosynthesis

J Liu, L Han, G Li, A Zhang, X Liu, M Zhao - Frontiers in Genetics, 2023 - frontiersin.org
Veratrum mengtzeanum is the main ingredient for Chinese folk medicine known as
“Pimacao” due to its unique alkaloids. A diverse class of plant-specific metabolites having …

[HTML][HTML] Functional characterization of key polyketide synthases by integrated metabolome and transcriptome analysis on curcuminoid biosynthesis in Curcuma …

R Chen, T Hu, M Wang, Y Hu, S Chen, Q Wei… - Synthetic and Systems …, 2022 - Elsevier
Leaf and tuber extracts of Curcuma wenyujin contain a mixture of curcuminoids. However,
the curcuminoid constituents and their molecular mechanisms are poorly understood, and …

Suspect screening and targeted analysis of acyl coenzyme A thioesters in bacterial cultures using a high-resolution tribrid mass spectrometer

N Cakić, B Kopke, R Rabus, H Wilkes - Analytical and Bioanalytical …, 2021 - Springer
Abstract Analysis of acyl coenzyme A thioesters (acyl-CoAs) is crucial in the investigation of
a wide range of biochemical reactions and paves the way to fully understand the concerned …