The 1013–1014 microorganisms present in the human gut (collectively known as the human
gut microbiota) dedicate substantial percentages of their genomes to the degradation and …

The genome of gut microbes encodes a collection of enzymes whose metabolic functions
contribute to the bioavailability and bioactivity of unabsorbed (poly) phenols. Datasets from …

Human genetic variation affects the gut microbiota through a complex combination of
environmental and host factors. Here we characterize genetic variations associated with …

The human gut microbiome composition is generally in a stable dynamic equilibrium, but it
can deteriorate into dysbiotic states detrimental to host health. To disentangle the inherent …

Glycoscience assembles all the scientific disciplines involved in studying various molecules
and macromolecules containing carbohydrates and complex glycans. Such an ensemble …

The design of structurally diverse enzymes is constrained by long-range interactions that are
necessary for accurate folding. We introduce an atomistic and machine learning strategy for …

Glycoside hydrolase family (GH) 16 comprises a large and taxonomically diverse family of
glycosidases and transglycosidases that adopt a common β-jelly-roll fold and are active on a …

Algae synthesise structurally complex glycans to build a protective barrier, the extracellular
matrix. One function of matrix glycans is to slow down microorganisms that try to …

Microbes and their carbohydrate-active enzymes are central for depolymerization of
complex lignocellulosic polysaccharides in the global carbon cycle. Their unique abilities to …

The term “starch-binding domain”(SBD) has been applied to a domain within an amylolytic
enzyme that gave the enzyme the ability to bind onto raw, ie thermally untreated, granular …