Strained conformations of nucleosides in active sites of nucleoside phosphorylases

IA Il'icheva, KM Polyakov, SN Mikhailov - Biomolecules, 2020 - mdpi.com
Nucleoside phosphorylases catalyze the reversible phosphorolysis of nucleosides to
heterocyclic bases, giving α-d-ribose-1-phosphate or α-d-2-deoxyribose-1-phosphate …

UHPLC-MSn-assisted characterization of bioactive alkaloids extracted from Nitraria sibirica leaves and enriched using response surface method and adsorption on …

C Turghun, M Bakri, R Abudulla, GY Sun… - Industrial Crops and …, 2018 - Elsevier
Abstract In Xinjiang, China, Nitraria sibirica Pall. is traditionally used to treat hypertension,
menstrual disorders, and gastroenteritis. Following process optimization by response …

QM/MM Study of a Nucleophilic Substitution Reaction Catalyzed by Uridine Phosphorylase from Vibrio cholerae

AA Lashkov, PA Eistrich-Geller, VR Samygina… - Crystals, 2023 - mdpi.com
Uridine phosphorylases are used for biotechnological synthesis of pyrimidine derivatives
and, moreover, their substrates and inhibitors are used in medicine. Therefore, studies of the …

X-ray Structural Studies of Proteins at the Shubnikov Institute of Crystallography of the Russian Academy of Sciences

IP Kuranova, AA Lashkov, VR Samygina - Crystallography Reports, 2024 - Springer
The development and formation of X-ray crystallography of macromolecules, or protein
crystallography, is one of the most important achievements of science in the 20th century …

X-Ray Structure and Molecular Dynamics Study of Uridine Phosphorylase from Vibrio cholerae in Complex with 2,2'-Anhydrouridine

PA Eistrikh-Heller, SV Rubinsky, II Prokofev… - Crystallography …, 2020 - Springer
The high-resolution three-dimensional structure of uridine phosphorylase from the
pathogenic bacterium Vibrio cholerae in complex with the competitive inhibitor 2, 2' …