Targeting mechanisms of tailed bacteriophages

FL Nobrega, M Vlot, PA De Jonge… - Nature Reviews …, 2018 - nature.com
Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Comparative genomics reveals electron transfer and syntrophic mechanisms differentiating methanotrophic and methanogenic archaea

GL Chadwick, CT Skennerton, R Laso-Pérez… - PLoS …, 2022 - journals.plos.org
The anaerobic oxidation of methane coupled to sulfate reduction is a microbially mediated
process requiring a syntrophic partnership between anaerobic methanotrophic (ANME) …

[HTML][HTML] Programmable protein delivery with a bacterial contractile injection system

J Kreitz, MJ Friedrich, A Guru, B Lash, M Saito… - Nature, 2023 - nature.com
Endosymbiotic bacteria have evolved intricate delivery systems that enable these organisms
to interface with host biology. One example, the extracellular contractile injection systems …

Viruses defined by the position of the virosphere within the replicator space

EV Koonin, VV Dolja, M Krupovic… - … and Molecular Biology …, 2021 - Am Soc Microbiol
Originally, viruses were defined as miniscule infectious agents that passed through filters
that retain even the smallest cells. Subsequently, viruses were considered obligate …

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

EV Koonin, KS Makarova, YI Wolf… - Nature Reviews …, 2020 - nature.com
All cellular life forms are afflicted by diverse genetic parasites, including viruses and other
types of mobile genetic elements (MGEs), and have evolved multiple, diverse defence …

Activity, delivery, and diversity of Type VI secretion effectors

D Jurėnas, L Journet - Molecular Microbiology, 2021 - Wiley Online Library
The bacterial type VI secretion system (T6SS) system is a contractile secretion apparatus
that delivers proteins to neighboring bacterial or eukaryotic cells. Antibacterial effectors are …

[HTML][HTML] A perfect fit: Bacteriophage receptor-binding proteins for diagnostic and therapeutic applications

J Klumpp, M Dunne, MJ Loessner - Current opinion in microbiology, 2023 - Elsevier
Bacteriophages are the most abundant biological entity on earth, acting as the predators
and evolutionary drivers of bacteria. Owing to their inherent ability to specifically infect and …

Structure and activity of the type VI secretion system

Y Cherrak, N Flaugnatti, E Durand, L Journet… - Microbiology …, 2019 - Am Soc Microbiol
The type VI secretion system (T6SS) is a multiprotein machine that uses a spring-like
mechanism to inject effectors into target cells. The injection apparatus is composed of a …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Evolutionary and ecological role of extracellular contractile injection systems: from threat to weapon

CM Heiman, J Vacheron, C Keel - Frontiers in Microbiology, 2023 - frontiersin.org
Contractile injection systems (CISs) are phage tail-related structures that are encoded in
many bacterial genomes. These devices encompass the cell-based type VI secretion …